Cog数据库中每个字母都代表什么功能？Cog中注释的结果既有M还有mot，mot是属于m吗？

目前COG分类中每个字母代表的功能分类含义：

 

INFORMATION STORAGE AND PROCESSING

[J] Translation, ribosomal structure and biogenesis

[A] RNA processing and modification

[K] Transcription

[L] Replication, recombination and repair

[B] Chromatin structure and dynamics

 

CELLULAR PROCESSES AND SIGNALING

[D] Cell cycle control, cell division, chromosome partitioning

[Y] Nuclear structure

[V] Defense mechanisms

[T] Signal transduction mechanisms

[M] Cell wall/membrane/envelope biogenesis

[N] Cell motility

[Z] Cytoskeleton

[W] Extracellular structures

[U] Intracellular trafficking, secretion, and vesicular transport

[O] Posttranslational modification, protein turnover, chaperones

 

METABOLISM

[C] Energy production and conversion

[G] Carbohydrate transport and metabolism

[E] Amino acid transport and metabolism

[F] Nucleotide transport and metabolism

[H] Coenzyme transport and metabolism

[I] Lipid transport and metabolism

[P] Inorganic ion transport and metabolism

[Q] Secondary metabolites biosynthesis, transport and catabolism

 

POORLY CHARACTERIZED

[R] General function prediction only

[S] Function unknown

 

如果一个序列被注释为属于COG分类中的M，那么它主要涉及细胞壁/膜/包被的生物合成功能。"mot"是"M"的一个子类或者相关类别，代表细胞膜生物合成相关的功能。

 

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COG功能注释分析